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pentobarbital will decrease the level or influence of pantoprazole by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Significance Unidentified.pentobarbital increases toxicity of methoxyflurane by increasing metabolism. Contraindicated. Increased metabolism of methoxyflurane to nephrotoxic compounds.
pentobarbital will decrease the extent or effect of osilodrostat by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
With therapeutic doses of TCAs, barbiturates increase metabolism and reduce blood concentrations of TCAs.
pentobarbital will minimize the level or result of lorlatinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism.
pentobarbital will decrease the level or effect of tramadol by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Decreased AUC of tramadol plus the active metabolite (O-desmethyltramadol) when coadministered with sturdy CYP3A4 and CYP2B6 inducers
pentobarbital decreases amounts of ponatinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Stay clear of Until the coadministration outweighs the possible danger of ponatinib underexposure; keep track of for indications of lessened efficacy.
Contraindicated (one)pentobarbital will minimize the extent or impact of lonafarnib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Lonafarnib is a sensitive CYP3A4 substrate. Coadministration with strong or average CYP3A4 inducers is contraindicated.
Use an alternate method of contraception or even a backup technique when enzyme inducers are utilized with blended hormonal contraceptives (CHCs), and go on backup contraception for 28 days after discontinuing enzyme inducer to be sure contraceptive reliability.
pentobarbital will lessen the extent or influence of tacrolimus by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on.
pentobarbital will reduce the extent or influence of bosentan by impacting hepatic/intestinal enzyme CYP3A4 click here metabolism. Small/Importance Mysterious.
This drug may interfere with the absorption of orally administered griseofulvin, reducing its blood amounts; effects of blood degree reduction not known; preferable in order to avoid concomitant administration of these medications
pentobarbital will lessen the level or effect of eplerenone by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Significance Not known.
Monoamine oxidase inhibitors (MAOI) may inhibit barbiturate metabolism and lengthen barbiturate outcomes; observe closely